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Pubblicazioni Scientifiche

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2008 Kwakman et al in CID[2][1]

2008 Kwakman et al in CID[2][1]

Medical-Grade Honey Kills Antibiotic-Resistant Bacteria In Vitro and Eradicates Skin Colonization

Paulus H. S. Kwakman,1,2 Johannes P. C. Van den Akker,3 Ahmet Gu ̈c ̧lu ̈,1,3 Hamid Aslami,1,3 Jan M. Binnekade,3 Leonie de Boer,1 Laura Boszhard,1 Frederique Paulus,3 Pauline Middelhoek,3 Anje A. te Velde,2 Christina M. J. E. Vandenbroucke-Grauls,1,4 Marcus J. Schultz,3 and Sebastian A. J. Zaat1

1Department of Medical Microbiology and 2Center for Experimental and Molecular Medicine, Center for Infection and Immunity Amsterdam, and 3Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, and 4Department of Medical Microbiology and Infectious Diseases, Free University Medical Center, Amsterdam, The Netherlands

See link below to paper 

2008 Kwakman et al in CID[2][1]

 

Revamilartikel engels vs 2[1]

Revamilartikel engels vs 2[1]

Published in WCS News, dec 2006

Sweet after acid

Revamil Honey gel, a successful remedy for wounds

W. van Eijk en O. Groenhart*

Introduction

In recent years, the number of patients with difficult to heal wounds has increased significantly. Several developments effect the increase of patients with chronic wounds:

  •  On average 4,4% of the total population in the UK suffers from Diabetus Mellitus, equating to 2.2 million (Forouhi, 2006). The estimated number of Americans with diagnosed diabetes is projected to increase 165%, from 11 million in 2000 (prevalence of 4.0%) to 29 million in 2050 (prevalence of 7.2%) (Boyle, 2001). About 25% of all diabetes patients will need specialised medical care during the course of there illness, while 10% will develop diabetic foot ulcers.

  •  The proportional increase of the ageing population causes an increase of patients with venous leg ulcers. The prevalence of venous leg ulcers is 1% over the total population, but equates to 4 to 5% for people aged >80 in The Netherlands.

See link below to paper

Revamilartikel engels vs 2[1]

L’utilizzo delle medicazioni naturali avanzate nel trattamento delle ulcere venose

L’utilizzo delle medicazioni naturali avanzate nel trattamento delle ulcere venose

ESPERIENZE

L’utilizzo delle medicazioni naturali avanzate nel trattamento delle ulcere venose
di Elisa Cereda (1), Lorena Sa/vini (2), Rino Corrarello (3), Maria Granate/li (4)

(1) Infermiera Libera professionista
(2) Tutor Corso di laurea in Infermieristica, Università degli Studi di Milano Bicocca
(3) Infermiere Esperto Wound Care, AO ICP Bassini
(4) Coordinatrice Infermieristica, AO ICP Bassini

Corrispondenza: elicere92@gmail.com

Le medicazioni naturali avanzate a base di miele sono state utilizzate come medicazioni topiche sin dall’antichità per la gestione delle lesioni cutanee, in particolare per le ulcere venose, in relazione alle loro proprietà antibatteriche. Con l’awento dell’antibiotico terapia, tali medicazioni sono state abbandonate per poi essere reintrodotte nella pratica clinica a seguito dello sviluppo di resistenze batteriche. Infatti, a differenza delle medicazioni convenzionalmente utilizzate nel trattamento delle ulcere venose e dell’antibiotico terapia, le medicazioni a base di miele ad oggi non sembrerebbero presentare alcun tipo di resistenza batterica (Knight, 2013). Nello studio riportato verranno analizzate due tipologie differenti di miele sotto forma di gel:

Manuka e Revamil®.

L’utilizzo delle medicaz…CM – Federazione IPASVI [590467]

Kwakman FASEB[1]

Kwakman FASEB[1]

The FASEB Journal article fj.09-150789. Published online March 12, 2010.

The FASEB Journal • Research Communication

How honey kills bacteria

Paulus H. S. Kwakman,* Anje A. te Velde,† Leonie de Boer,* Dave Speijer,‡ Christina M. J. E. Vandenbroucke-Grauls,*,§ and Sebastian A. J. Zaat*,1

*Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, †Laboratory of Experimental Gastroenterology and Hepatology, and ‡Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam; and §Department of Medical Microbiology and Infectious Diseases, Vrije Universiteit Medical Center, Amsterdam, The Netherlands

See link below to paper 

Kwakman FASEB[1]

Honey dressing versus silver sulfadiazene dressing for wound healing in burn patients_ A retrospective study _[PAUTHORS], Journal of Cutaneous and Aesthetic Surgery (JCAS)

Honey dressing versus silver sulfadiazene dressing for wound healing in burn patients_ A retrospective study _[PAUTHORS], Journal of Cutaneous and Aesthetic Surgery (JCAS)

ORIGINAL ARTICLE

Year : 2011 | Volume : 4 | Issue : 3 | Page : 183–187

Honey dressing versus silver sulfadiazene dressing for wound healing in burn patients: A retrospective study

Shilpi Singh Gupta, Onkar Singh, Praveen Singh Bhagel, Sonia Moses, Sumit Shukla, Raj Kumar Mathur
Department of Surgery, MGM Medical College and MY Hospital, Indore, Madhya Pradesh, India

Correspondence Address:
Shilpi Singh Gupta
Sangowal, Nakodar, Jalandhar – 144 041, Punjab
India

Abstract

Objective : The aim was to evaluate the effect of honey dressing and silver sulfadiazene (SSD) dressing on wound healing in burn patients. Materials and Methods : We retrospectively reviewed the records of 108 patients (14-68 years of age), with first and second degree burns of less than 50% of the total body surface area admitted to our institution, over a period of 5 years (2004-2008). Fifty-one patients were treated with honey dressings and 57 with SSD. Time elapsed since burn, site, percentage, degree and depth of burns, results of culture sensitivity at various time intervals, duration of healing, formation of post-treatment hypertrophic scar, and/or contracture were recorded and analyzed. Results : The average duration of healing was 18.16 and 32.68 days for the honey and SSD group, respectively. Wounds of all patients reporting within 1 h of burns became sterile with the honey dressing in less than 7 days while there was none with SSD. All wounds treated with honey became sterile within 21 days while for SSD-treated wounds, this figure was 36.5%. A complete outcome was seen in 81% of all patients in the «DQ»honey group«DQ» while in only 37% patients in the «DQ»SSD group.«DQ» Conclusion : Honey dressings make the wounds sterile in less time, enhance healing, and have a better outcome in terms of hypertropic scars and postburn contractures, as compared to SSD dressings.

See link below to paper

Honey dressing versus silver sulfadiazene dressing for wound healing in burn patients_ A retrospective study _[PAUTHORS], Journal of Cutaneous and Aesthetic Surgery (JCAS)

Two Major Medicinal Honeys Have Different Mechanisms…

Two Major Medicinal Honeys Have Different Mechanisms…

Two Major Medicinal Honeys Have Different Mechanisms of Bactericidal Activity

Paulus H. S. Kwakman1, Anje A. te Velde2, Leonie de Boer1, Christina M. J. E. Vandenbroucke-Grauls1,3, Sebastian A. J. Zaat1*

1 Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, 2Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, 3Department of Medical Microbiology and Infectious Diseases, VU Medical Center, Amsterdam, The Netherlands

Abstract

Honey is increasingly valued for its antibacterial activity, but knowledge regarding the mechanism of action is still incomplete. We assessed the bactericidal activity and mechanism of action of RevamilH source (RS) honey and manuka honey, the sources of two major medical-grade honeys. RS honey killed Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa within 2 hours, whereas manuka honey had such rapid activity only against B. subtilis. After 24 hours of incubation, both honeys killed all tested bacteria, including methicillin-resistant Staphylococcus aureus, but manuka honey retained activity up to higher dilutions than RS honey. Bee defensin-1 and H2O2 were the major factors involved in rapid bactericidal activity of RS honey. These factors were absent in manuka honey, but this honey contained 44-fold higher concentrations of methylglyoxal than RS honey. Methylglyoxal was a major bactericidal factor in manuka honey, but after neutralization of this compound manuka honey retained bactericidal activity due to several unknown factors. RS and manuka honey have highly distinct compositions of bactericidal factors, resulting in large differences in bactericidal activity.

See link below to paper

two major medicinal honeys have different mechanism…

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